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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1897 1
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1902 2
1945 18
1946 40
1947 65
1948 71
1949 93
1950 110
1951 139
1952 171
1953 139
1954 158
1955 164
1956 136
1957 147
1958 132
1959 138
1960 154
1961 173
1962 164
1963 238
1964 447
1965 361
1966 347
1967 423
1968 558
1969 545
1970 586
1971 649
1972 674
1973 701
1974 767
1975 739
1976 680
1977 694
1978 715
1979 768
1980 810
1981 868
1982 920
1983 921
1984 1071
1985 1273
1986 1322
1987 1272
1988 1354
1989 1368
1990 1368
1991 1438
1992 1469
1993 1435
1994 1551
1995 1703
1996 1687
1997 1765
1998 1882
1999 1800
2000 1919
2001 1816
2002 1850
2003 1962
2004 1949
2005 1861
2006 1766
2007 1748
2008 1620
2009 1675
2010 1591
2011 1613
2012 1650
2013 1526
2014 1407
2015 1341
2016 1369
2017 1215
2018 1107
2019 1152
2020 1113
2021 1071
2022 1093
2023 1039
2024 362

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Page 1
Slow thrombin is zymogen-like.
Huntington JA. Huntington JA. J Thromb Haemost. 2009 Jul;7 Suppl 1(S1STATE):159-64. doi: 10.1111/j.1538-7836.2009.03365.x. J Thromb Haemost. 2009. PMID: 19630791 Free PMC article. Review.
In this manuscript, I will review the general features that render zymogens inactive and how proteolytic cleavage results in activation, but I will also show how this distinction is blurred by zymogens that have activity (protease-like zymogens) and proteases …
In this manuscript, I will review the general features that render zymogens inactive and how proteolytic cleavage results in activati …
Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection.
Windsor IW, Dudley DM, O'Connor DH, Raines RT. Windsor IW, et al. AIDS Res Ther. 2021 Oct 26;18(1):77. doi: 10.1186/s12981-021-00399-z. AIDS Res Ther. 2021. PMID: 34702287 Free PMC article.
METHODS: We engineered amino acid substitutions that enable human RNase 1 to evade RI upon its cyclization into a zymogen that is activated by the HIV-1 protease. In effect, the zymogen has an HIV-1 protease cleavage site between the termini of the wild-type enzy …
METHODS: We engineered amino acid substitutions that enable human RNase 1 to evade RI upon its cyclization into a zymogen that is act …
Mechanisms of intracellular zymogen activation.
Gorelick FS, Otani T. Gorelick FS, et al. Baillieres Best Pract Res Clin Gastroenterol. 1999 Jul;13(2):227-40. doi: 10.1053/bega.1999.0021. Baillieres Best Pract Res Clin Gastroenterol. 1999. PMID: 11030603 Review.
The pancreatic acinar cell is potentially the initial site of injury that begins the series of events leading to acute pancreatitis. Pathological intrapancreatic zymogen activation occurs in experimental pancreatitis in animals and in human pancreatitis. ...Recent studies …
The pancreatic acinar cell is potentially the initial site of injury that begins the series of events leading to acute pancreatitis. Patholo …
New insights into the hemolymph coagulation cascade of horseshoe crabs initiated by autocatalytic activation of a lipopolysaccharide-sensitive zymogen.
Kawabata SI, Shibata T. Kawabata SI, et al. Dev Comp Immunol. 2022 Oct;135:104491. doi: 10.1016/j.dci.2022.104491. Epub 2022 Jul 16. Dev Comp Immunol. 2022. PMID: 35850280 Review.
The concept of a chain reaction of proteolytic activation of multiple protease zymogens was first proposed to explain the blood clotting system in mammals as an enzyme cascade. In multicellular organisms, similar enzyme cascades are widely present in signal t …
The concept of a chain reaction of proteolytic activation of multiple protease zymogens was first proposed to explain the blood clott …
Zymogen and activated protein C have similar structural architecture.
Stojanovski BM, Pelc LA, Zuo X, Di Cera E. Stojanovski BM, et al. J Biol Chem. 2020 Nov 6;295(45):15236-15244. doi: 10.1074/jbc.RA120.014789. Epub 2020 Aug 27. J Biol Chem. 2020. PMID: 32855236 Free PMC article.
Activated protein C is a trypsin-like protease with anticoagulant and cytoprotective properties that is generated by thrombin from the zymogen precursor protein C in a reaction greatly accelerated by the cofactor thrombomodulin. ...This scenario stands in contrast to an an …
Activated protein C is a trypsin-like protease with anticoagulant and cytoprotective properties that is generated by thrombin from the zy …
Matriptase zymogen supports epithelial development, homeostasis and regeneration.
Friis S, Tadeo D, Le-Gall SM, Jürgensen HJ, Sales KU, Camerer E, Bugge TH. Friis S, et al. BMC Biol. 2017 Jun 1;15(1):46. doi: 10.1186/s12915-017-0384-4. BMC Biol. 2017. PMID: 28571576 Free PMC article.
Compatible with these observations, wildtype and zymogen-locked matriptase were equipotent activators of PAR-2 inflammatory signaling. CONCLUSION: The study demonstrates that the matriptase zymogen is biologically active and is capable of executing developmental and …
Compatible with these observations, wildtype and zymogen-locked matriptase were equipotent activators of PAR-2 inflammatory signaling …
An active zymogen: unravelling the mystery of tissue-type plasminogen activator.
Stubbs MT, Renatus M, Bode W. Stubbs MT, et al. Biol Chem. 1998 Feb;379(2):95-103. doi: 10.1515/bchm.1998.379.2.95. Biol Chem. 1998. PMID: 9524060 Review.
In contrast to almost all other proteinases, human tissue-type plasminogen activator (tPA) is also proteolytically active in its zymogen or single-chain form. The closely related plasminogen activator isolated from vampire bat saliva (vPA) acts exclusively in the single-ch …
In contrast to almost all other proteinases, human tissue-type plasminogen activator (tPA) is also proteolytically active in its zymogen …
Structure and zymogen activation of caspases.
Donepudi M, Grütter MG. Donepudi M, et al. Biophys Chem. 2002 Dec 10;101-102:145-53. doi: 10.1016/s0301-4622(02)00151-5. Biophys Chem. 2002. PMID: 12487996 Review.
Apoptosis is primarily executed by active caspases, which are derived from the inactive zymogens. Structural and biochemical studies of caspases-1, -3, -7, -8 and -9 have greatly enhanced our understanding of the structure, function, and specificity of the active form of t …
Apoptosis is primarily executed by active caspases, which are derived from the inactive zymogens. Structural and biochemical studies …
Modifying a bacterial tyrosinase zymogen for use in protease activity assays.
Zhang J, Huang W, Zhang L, Tang X, Sun G, Zou L. Zhang J, et al. Appl Microbiol Biotechnol. 2022 Dec;106(24):8285-8294. doi: 10.1007/s00253-022-12284-4. Epub 2022 Nov 21. Appl Microbiol Biotechnol. 2022. PMID: 36404357
Here, we designed three different zymogen constructs of Vs-tyrosinase, including RSL-pre-pro-TYR, Pre-pro-TYR, and Pro-TYR. ...N-pre and C-terminal domain exerted stronger dual inhibition on the Vs-tyrosinase. The activity of caspase-3 could be measured by the zymogen …
Here, we designed three different zymogen constructs of Vs-tyrosinase, including RSL-pre-pro-TYR, Pre-pro-TYR, and Pro-TYR. ...N-pre …
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